A team of Italian researchers recently discovered that a simple experimental breath test can diagnose colorectal cancer with over 75% accuracy. Results of the study, which were determined using thermal-desorber gas chromatography-mass spectrometry (GC-MS), showed that the exhaled breath of cancer patients contained volatile organic compounds (VOCs) different from those in people without cancer. The study has been published in the British Journal of Surgery.
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The method works by detecting VOCs emitted by cancerous tissue, a technique that has been used in diagnostics for several cancers and gastrointestinal disorders. The researchers collected exhaled breath samples from 37 people with colorectal cancer and 41 people without. The breath samples were then evaluated using thermal-desorber GC-MS to find traces and patterns of VOCs that might indicate cancer.
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Findings indicate that a pattern of 15 VOCs was linked with colorectal cancer. These patterns discriminated cancer cases with 86% sensitivity, 83% specificity, and 85% accuracy. Final results showed that 19 of the people with colorectal cancer were correctly diagnosed with colorectal cancer from their breath samples.
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According to lead author Dr. Donato F. Altomare, M.D. of the University Aldo Moro of Bari, the study?s findings ?provide further support for the value of breath testing as a screening tool.? With this, researchers interested in extending the current use of breath tests now have additional reference with regards to the limitations of the method. To achieve accurate results, such research require the use of reliable and industry-standard gas chromatography systems. For any inquiries on high-quality GC systems, feel free to fill out the form at the left.
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Jamal Miah
Jamal Miah has a B.S. in Computer Science from Brunel University. He works at the Marketing & Web Communications department of GMI Inc.
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